When Is Baseball Opening Day 2025. Most opening day games will be played on the regional sports networks affiliated with each baseball club. Here's a look at the 2025 opening day schedule for thursday, march 27.

Well, in case you’re wondering — yes, this is (sort of, but not technically) the earliest opening day ever. The cincinnati reds will play host to the san francisco giants on opening day of the 2025 major league baseball season.